"I feel like Alexis, my sister, has taught me so much about love and acceptance. It’s a very difficult thing to be transgender, especially 20 years ago when Alexis started," Arquette said. "I didn't exactly understand it. But our father had died, our mother had died. I’d lost two people I loved. And we all come into this life in a different package – a baby package. We get older, we become an old person package. If you’re male or female, at the end I didn't care. I had people I loved who died. I said, 'I don’t care what package you’re comfortable in, I love and accept you. I am glad you are here on earth. I want to be with you, spend time with you.' It doesn't matter."
She went on to condemn the way that the media is handling the everything with the Kardashians/Jenners.
"These newspapers, these magazines, that are being so disrespectful. They should be ashamed. Because they really are on the unforgivable side of history and what they are doing is pathetic and immature and repulsive. So many young people commit suicide, don’t have acceptance. They’re diminished in society. They’re not allowed to work counters at stores, people make fun of them, snicker at them, attack them," she continued. "You have to be so brave to live this truth of who you are. If Ms. Jenner is transitioning, I give all my support to her and love and appreciate everything she has given to America and her bravery, because she is fighting a fight for a lot of kids that are being kicked out of their own homes—society turns their back on these kids. It’s really brutal"