The longtime friends and collaborators pose side by side wearing only messenger bags in a photo Franco posted on Instagram on Friday.
"Boom boom, NAKED and Afraid," the 36-year-old "Spring Breakers" star captioned the image, which blurs out their privates.
It's obviously a teaser for their next project, although it's not exactly clear what it will be.
However, "Naked and Afraid," as Franco wrote in all of the captions, is a docudrama series on the Discovery Channel that follows individuals forced to survive on their own without food, water or clothing.
As the 32-year-old "Neighbors" star and Franco have done several times in the past -- remember their spoof on Kanye West's "Bound 2" music video, starring Rogen as Kim Kardashian? -- the comedic duo may just be at it again.