Duchess of Cambridge is pregnant with her second child, Clarence House confirms
A statement said the Queen and members of both families were delighted with the news.
The palace said that - as when she was pregnant with Prince George - the duchess was suffering from very acute morning sickness and was being treated by doctors at Kensington Palace.
Prime Minister David Cameron tweeted he was "delighted by the happy news that they're expecting another baby".
The couple's second child will become fourth in line to the throne, moving Prince Harry further down the line of succession.
Clarence House said: "Their Royal Highnesses the Duke and Duchess of Cambridge are very pleased to announce that the Duchess of Cambridge is expecting their second child."
The duchess's morning sickness meant that she would no longer accompany Prince William on their planned engagement in Oxford on Monday, Clarence House said.
Catherine had been due to join William in formally opening a £21m China study centre at Oxford University.
The sickness - called hyperemesis gravidarum - is a condition that may require supplementary hydration, medication and nutrients.
The duchess had been due to carry out her first solo overseas tour in Malta later this month.
The baby announcement came two months after the couple's first child, Prince George, had his first birthday.
The Duke and Duchess of Cambridge are very pleased to announce that The Duchess of Cambridge is expecting their second child— Clarence House (@ClarenceHouse) September 8, 2014
The Queen and members of both families are delighted with the news that Their Royal Highnesses are expecting their second child— Clarence House (@ClarenceHouse) September 8, 2014
The couple's first child Prince George of Cambridge was born on the 22nd July 2013.