His representative at 3 Arts Entertainment confirmed DeStefano died Sunday in New York City. The representative wouldn't disclose DeStefano's age or the cause of death. Us Magazine reports DeStefano was 44.
Born in the Bronx, DeStefano was a former drug addict who became a drug counselor and then started a career in stand-up.
He played at clubs, made television appearances and performed at festivals. He came in fourth place on "Last Comic Standing."
DeStefano's death came just days before he was scheduled to perform his one-man show, "A Cherry Tree In The Bronx," in New York.
TVGuide.com reported that the comedian had just finished a run of shows titled "Drugs, Disease and Death: A Comedy," which was largely based on being HIV positive, his past drug addiction and his wife's death.
DeStefano finished fourth during Season 7 of the NBC comedy competition show. A judge from that same season, Greg Giraldo, died in September 2010.
i never saw him on last comic standing, but i knew of him from this story he told for The Moth, which was really beautiful. RIP.