Episodes: 12 (1 season)
What you can expect: Funny, Trippy, Unique, Chaotic, Magic, Fantasy, Mystery, Dystopian, Gritty, Action, Violence, Gore, Fight scenes, it explores the theme of friendship, has excellent world building, and a bunch of weird and interesting complex characters.
What it's about: Dorohedoro follows a man named Caiman who has a lizard for a head and amnesia about how he got it and who he really is. Caiman and his friend Nikaido are on the hunt for the sorcerer who cursed him with the scaly affliction. Living in a city simply called "Hole", Caiman and Nikaido chase down sorcerers who enter Hole using magic that creates a door between Hole and the world of sorcery. Hole has been ravaged by the magic of the sorcerers and has become a true nightmare city to live in and Caiman and Nikaido want to put a stop to it by killing these sorcerers. But before they kill a sorcerer, Caiman chomps down on their head so that the sorcerer can speak to the man living inside Caiman's mouth to determine whether or not the sorcerer is responsible for his curse (yes, there's a man living in his lizard mouth).
It sounds absolutely batshit insane - and it is! It's also incredibly fun, fast paced, goofy, and has a whole bunch of interesting and mysterious characters. There are only 12 episodes so it's an easy binge (whether we can expect a season 2 is still up in the air, so don't expect resolution and a story that wraps up neatly at the end).
Don't watch if you don't like: Violence and an unresolved ending.
TL;DR: A man with a lizard head hunts down the sorcerer that cursed him. It's better than you're expecting. I guarantee that even if you don't laugh, you'll blow hot air out of your nose at least once. Give it a try!
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I've purposefully left off more well known shows, multi-season shows (or shows with a large number of episodes), and frequently recommended titles like "Attack on Titan" and "Neon Genesis Evangelion" to keep the list a little bit more interesting, especially for those who have tried to get into more widely talked about shows but couldn't connect with them. These recommendations are also based entirely on the subtitled versions of the shows - I have no idea what the quality of the dubbing is like.
Sources: 1 / 2 / 3 / 4 / 5