Variety he revealed that Sam Raimi of the Tobey McGuire Spider-Man trilogy is in talks (Hollywood speak for as good as a done deal) to direct "Doctor Strange and the Multiverse of Madness" following Scott Derickson's exit.
Meanwhile Collider's Jeff Sneider has revealed that Rachel McAdams, who played Stranger's love interest Dr. Christine Palmer will.likwy not be returning for the sequel.
Rachel McAdams not expected to return for DOCTOR STRANGE sequel. Hmmm...— Jeff Sneider (@TheInSneider) February 6, 2020
source 2: https://twitter.com/TheInSneider/status/1225211663608991744