Amanda Seyfried reveals she turned down the chance to play Gamora in the Marvel Cinematic Universe.
"I turned down [a superhero movie] once and they haven’t called back since. And it was a big’un. I don’t regret it because I didn’t want to be green for six months out of every year. They tell beautiful stories through superheroes, and my daughter’s now really obsessed with superheroes now, and part of me wishes I’d done it, but the other part of me is like ‘I had a life to live’ and I don’t think I would’ve been happy."
While she never namedrops Gamora specifically, those details seem to indicate that Seyfried would have had the part that eventually went to Saldana.