Chelsea Handler's Chelsea Lately ended its seven-year run Tuesday night, and the host was duly impressed.
"I've made great friends, a lot of enemies, and I have personally lost and gained 3,500 pounds."
The guest-star-jammed finale included cameos from a galaxy of stars, like Ellen DeGeneres, who demanded to know why she was never invited to be on the show
Other guests for the evening included Sandra Bullock, Jennifer Aniston and Handler's ex 50 Cent. Miley Cyrus was on hand to perform as well, though the evening's biggest musical moment was saved for last.