Tom Hanks and Meg Ryan could reunite in "Ithaca"

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Tom Hanks is in talks to reunite with his Sleepless in Seattle co-star star Meg Ryan in Ithaca, the film adaptation of William Saroyan's classic 1943 novel The Human Comedy that marks the actress' directorial debut.

Hanks would make a cameo in the Word War II coming-of-age saga about life on the home front. He's already closely involved in the project, serving as executive producer alongside his partner at Playtone, Gary Goetzman.

Ithaca will mark the fourth time that Hanks and Ryan have appeared on the big screen together after Joe Versus the Volcano, Sleepless in Seattle and You've got Mail, their last film and released in 1998.

Set in a small town in California's San Joaquin Valley in 1942, Ithaca recounts the story of 14-year-old Homer Macauley, a telegraph bike messenger. His older brother has gone to fight in World War II, leaving him to care for his widowed mother, his older sister and his four-year-old brother, Ulysses. The effects of the war are revealed as Homer delivers messages of love, friendship, pain and death, including one message that alters his own life forever. Hanks would play the boy's father, who is sent off to war and seen via flashbacks.